刘文佳 

    刘文佳，博士，西安交通大学第二附属医院生物诊疗中心特聘教授，博士生导师，西安交通大学“青年拔尖人才”A类人才，英国卡迪夫大学及首尔大学访问学者。

    参与获得陕西省科技进步一等奖2项，获得陕西省优秀博士论文。担任中国生物医学工程学会组织工程与再生医学分会常务委员、中华口腔医学会口腔生物医学专业委员会委员。担任西安组织工程与再生医学研究所副所长。主持国家自然科学基金面上项目2项、青年项目1项。承担国家重点研发计划子课题2项，是教育部“创新团队”核心成员，国家自然科学基金重点项目及国际合作与交流项目学术骨干。主要从事干细胞功能调控与重大疾病治疗及康复研究。近年来发表SCI论文25篇，其中以第一作者和通讯作者发表SCI论文20篇，累计影响因子125。其中影响因子10分以上1篇，5分以上15篇，论文在Bone Research、Theranostics、Aging Cell、Aging等杂志发表。相关研究获2018年第七届口腔生物医学优秀青年研究一等奖、2017年第一届中国组织工程与再生医学优秀青年研究奖，2012年IADR青年学者研究奖。获实用新型专利2项、外观专利2项、申请发明专利5项。受邀参编“十二五”规划研究生教材等3部书籍。     

代表性论文：

1.     Zhang Zhang#, Shuai Yi#, Zhou Feng, Yin Jikai, Hu Jiachen, Guo Songling, Wang Yan,Liu Wenjia*.PDLSCs Regulate Angiogenesis of Periodontal Ligaments via VEGF Transferred by Exosomes in Periodontitis.Int J Med Sci. 2020 Feb 10;17(5):558-567.

2.     Zhang Zhang#, Zhang Liqiang#, Zhou You, Li Liya, Zhao Jiangdong, Qin Wen, Jin Zuolin,Liu Wenjia*.Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia. Cell Death Dis. 2019 Jul 18;10(8):552.

3.     Liu Wenjia#, Zhang Liqiang#, Xuan Kun, Hu Chenghu, Liu Shiyu, Liao Li, Li Bei, Jin Fang, Shi Songtao, Jin Yan*.Alplprevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells. Bone Res. 2018; 6: 27.

4.     Zhang Zhang#, Liqiang Zhang#, You Zhou#, Liya Li, Jiangdong Zhao, Wen Qin, Zuolin Jin*,Wenjia Liu*.Increase of HDAC9 restrains myoblast differentiation via epigenetically regulation of autophagy in hypoxia. Cell Death Dis. 2019

5.     Liu Wenjia#, Zhang Liqiang#, Xuan Kun#, Hu Chenghu, Li Liya, Zhang Yongjie, Jin Fang*, Jin Yan*. Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia. Theranostics. 2018; 8(20): 5575-5592.

6.     Li Liya#,Liu Wenjia#, Wang Hong, Yang Q, Zhang L, Jin F*, Jin Y*. Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions. Cell Death Dis. 2018; 9(5): 480. 

7.     Shuai Yi#, Ma Yang#, Guo Tao#, Zhang Liqiang, Yang Rui, Qi Meng,Liu Wenjia*, Jin Yan*. Dental Stem Cells and Tooth Regeneration. Adv Exp Med Biol. 2018; 1107: 41-52. 

8.     Ma Yang#, Qi Meng#, An Ying, Zhang Liqiang, Yang Rui, Doro H Daniel,Liu Wenjia*, Jin Yan*. Autophagy controls mesenchymal stem cell properties and senescence during bone aging. Aging Cell. Aging Cell. 2018; 17(1). 

9.     Qi Meng#, Zhang Liqiang#, Ma Yang#, Shuai Yt, Li Liya, Luo Kefu,Liu Wenjia*, Jin Yan*. Autophagy Maintains the Function of Bone Marrow Mesenchymal Stem Cells to Prevent Estrogen Deficiency-Induced Osteoporosis. Theranostics. 2017; 7(18): 4498-4516. 

10.  An Ying#,Liu Wenjia#, Xue Peng, Ma Yang, Zhang Liqiang, Zhu Bin, Qi Meng, Li Liya, Zhang Yongjie, Wang Qingtao*, Jin Yan*. Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion. Cell Death Dis. 2018; 9(2): 58. 

11.  Zhu Bin#,Liu Wenjia#, Liu Yihan, Zhao Xicong, Zhang Hao, Luo Zhuojing*, Jin Yan*. Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells. Sci Rep. 2017; 7: 40088.

12.  Zhang Liqiang#,Liu Wenjia#, Zhao Jiangdong, Ma Xiaojie, Shen Linlin, Zhang Yongjie, Jin Fang*, Jin Yan*. Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/β-catenin pathway. Biochim Biophys Acta. 2016; 860(10): 2211-2219. 

13.  An Ying#,Liu Wenjia#,Xue Peng, Zhang Yongjie, Wang Qintao*, Jin Yan*. Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment. J Clin Periodontol. 2016; 43(7): 618-625. 

14.  Liu Wenjia#, Qi Meng#, Konermann Anna#, Zhang Liqiang, Jin Fang*, Jin Yan*. The p53/miR-17/Smurf1 pathway mediates skeletal deformitiesin an age-related model via inhibiting the function of mesenchymal stem cells. Aging-US. 2015; 7(3): 205-218.

15.  Guo Tao#, Zhang Liqiang#, Konermann Anna, Zhou Hong, Jin Fang*,Liu Wenjia*. Manganese superoxide dismutase isrequired to maintain osteoclastdifferentiation and function under staticforce. Sci Rep.2015; 5: 8016.

16.  Zhu Bin#,Liu Wenjia#, Zhang Hao#, Zhao Xicong, Duan Yan, Li Dehua*, Jin Yan*. Tissue-specific composite cell aggregates drive periodontium tissue regeneration by reconstructing a regenerative microenvironment. J Tissue Eng Regen Med. 2017; 11(6): 1792-1805. 

17.  Liu Jia#, Wang Liying#,Liu Wenjia#, Li Qiang, Jin Zuolin*, Jin Yan*. Dental follicle cells rescue the regenerative capacity of periodontal ligament stem cells in an inflammatory microenvironment. PLoS One. 2014; 9(9): e108752. 

18.  Liu Wenjia#, Liu Yali#, Guo Tao, Hu Chenghu, Luo Hailang, Zhang Liqiang, Shi Songtao, Cai Tao, Ding Yin*, Jin Yan*. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. Cell Death Dis. 2013; 4: e539. 

19.  Liu Wenjia#, Konermann Anna#, Guo Tao#, Jäger Andreas, Zhang Liqiang, Jin Yan*. Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions. Biochim Biophys Acta. 2013; 1840(3): 1125-1134. 

20.  Liu Yali#,Liu Wenjia#,Hu Chenghu, Xue Zengfu, Wang Guang, Ding Bofu, Luo Hailang, Tang Liang, Kong Xiangwei, Chen Xiaoyan, Liu Na, Ding Yin*, Jin Yan*. MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis.Stem Cells. 2011; 29(11): 1804-1816.